Establishing a novel assay system for measuring renin concentration using cost effective recombinant ovine angiotensinogen
نویسندگان
چکیده
منابع مشابه
Escherichia coli-based production of recombinant ovine angiotensinogen and its characterization as a renin substrate
BACKGROUND Angiotensinogen (ANG) is a macromolecular precursor of angiotensin, which regulates blood pressure and electrolyte balance. ANG is specifically cleaved by renin, an aspartic protease, to initiate the angiotensin-processing cascade. Ovine ANG (oANG) from sheep plasma has been shown to be a better substrate for human renin, and it has been used in clinical renin assays. To expand the a...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2019
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2019.e01409